Synthesis Of Novel Compounds Derived From Dehydro Acetic Acid

I.H.AL-Bayati, Redha.

	Synthesis Of Novel Compounds Derived From Dehydro Acetic Acid
Al-Mustansiriyah Journal of Science
Article 1, Volume 24, Issue 3, 2013, Pages 41-56
Author
Redha. I.H.AL-Bayati
Abstract
In this work a new derivatives from dehydro acetic acid and its chalcone which synthesized from it, compounds [1,2] were synthesized from the reaction of chalcone(ch) with malononitrile in the presence of ammonium acetate, piperidine respectively. Also chalcone react with urea in basic medium to produce compound [3], while its treatment with urea, thiourea and hydroxyl amine in acidic medium gave compounds [4,5,6]. Ethylation of DHA gives compound [7] which when treated with nitrophenyl hydrazine and acetic acid produced compound [8]. Interestingly, when DHA itself reacted with phenyl hydrazine and acetic acid in the presence of sulfuric acid give compound [9]. Besides that, the Chloronation of DHA with POCl3, furnished compound [10] which reacts with aldehydes to give chalcone [11,12], and these chalcones cyclized with phenyl hydrazine and P-nitrophenyl hydrazine to yield [13,14] respectively. Schiff bases can be synthesized from DHA with amines to give [15,16,17], while [18,21] can be obtained from the reaction of [15,16]with POCl3 and DMF. Compounds [15,17] reacted with chloro acetyl chloride and gave (19,20). At last reaction of [17] with mercapto acetic acid produced [22]. All structures of synthesis compounds characterized by UV, FTIR and 1HMNR analysis for some of them.

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