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Synthesis Of Some New Tetrazole And 1,3-Diazetine Compounds | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 24, Issue 3, 2013, Pages 57-66 | ||
| Author | ||
| Jumbad H. Tomm | ||
| Abstract | ||
| A new series of heterocyclic compounds including four and five member rings have been synthesized. The new schiff bases derived from D-erythroascorbic acid were synthesized by condensation of D-erythroascorbic acid with aromatic amine (containing 1,3,4-oxadiazole or 1,3,4-thiadiazole unit) in dry benzene using glacial acetic acid as a catalyst. The new N-acyl compounds [XII]a-d were synthesized by addition reaction of acid chloride to imine group of Schiff bases in dry benzene . The new diazetine derivatives [XIII]a-d synthesized by the reaction of N-acyl with sodium azide in dimethylformamid . While the 1,3-cycloaddition reaction of sodium azide to Schiff bases compounds in dimethylformamid led to formation tetrazole compounds[XIV]a-c. All the synthesized compounds have been characterized by melting points , FTIR and 1HMNR (of some of theme) spectroscopy. The synthesized compounds have been screened for their antibacterial activities, they exhibited good antibacterial activity against Escherichia coli (G-) and Staphylococus aureus (G+) | ||
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