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The Relation between Serum Total Sialic Acid and the Presence of Metabolic Syndrome in Type 2 Diabetes Mellitus. | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 26, Issue 1, 2013, Pages 37-41 | ||
| Authors | ||
| Ikhlas K. Hammed; Baydaa A. Abed; Nada F. Rashid | ||
| Abstract | ||
| Abstract: Background: The metabolic syndrome comprises an array of cardiovascular disease (CVD) risk; the clustering of CVD risk factors in the metabolic syndrome suggests a common underlying mechanism. Circulating serum sialic acid, an inflammatory marker has recently been shown to be a strong predictor of cardiovascular mortality, and obesity-related diseases. Objective: is to study the relationship between serum total sialic acid and metabolic variables in type 2 diabetes with and without metabolic syndrome. Subject and Methods: One hundred type 2 diabetic mellitus patients (52 of them had metabolic syndrome and 48 without it) were recruited from the National Diabetic Center, Al-Mustansiriya University during the period from June 2011 to January 2012. One hundred apparently healthy control matched for age and sex were participated in this study. Fasting venous blood samples were collected from all participants, the level of HbA1c was estimated by high performance liquid chromatography. Total serum sialic acid (TSA) was estimated spectrophotometrically, Fasting Blood Glucose (FBG), Total cholesterol (TC), HDL-cholesterol (HDL-C), Triglycerides (TG) was measured and LDL cholesterol was calculated by Friedwald and Frederickson formula. Systolic, diastolic blood pressure, waist circumference, weight and height were determined for all participants. Statistical analysis was done using statistical package for social science (SPSS) version 17. Results: The study showed a significant graded increase of serum sialic acid, amongst the three groups of the studied population, with the lowest levels in non-diabetic subjects, intermediate levels in type 2 DM patients without metabolic syndrome and highest levels was in type 2 DM patients with metabolic syndrome and the mean serum TSA increased significantly as the components of the metabolic syndrome increases, statistically significant correlations were found between serum TSA and TC, TG, FBS, HbA1c. Conclusion: The elevated serum sialic acid concentration was strongly related to the presence of metabolic syndrome in type 2 diabetic subjects. Keywords: Serum total Sialic acid, metabolic syndrome, type 2 diabetes Mellitus | ||
| Keywords | ||
| Serum total Sialic acid; metabolic syndrome; Type | ||
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