Insulin Resistance and Risk of Chronic Renal Impairment in Non and Diabetic Iraqi Adults

Ali Hamdi, Rana; Kamal Rasheed, Manal; Kamal Rasheed, Mohammed

	Insulin Resistance and Risk of Chronic Renal Impairment in Non and Diabetic Iraqi Adults
Kerbala Journal of Medicine
Article 1, Volume 6, Issue 1, 2013, Pages 1514-1524 PDF (0 K)
Authors
Rana Ali Hamdi; Manal kamal Rasheed; Mohammed Kamal Rasheed
Abstract
background: Patients with chronic renal impairment (CRI) present a high prevalence of insulin resistance (IR). Chronic Renal Failure (CRF) is a syndrome of persistent renal impairment involving loss of glomeruli, tubular and nephron function. Dialysis may be used as a lineal treated to patients who have suddenly but temporarily, lost their kidney function (acute renal failure) or as a regular region for quite stable patients who have permanently lost their kidney function. Central obesity, particularly visceral adiposity is considered to play a major role in causing insulin resistance and type 2 diabetes mellitus. Insulin resistance is characterized by a decrease in the insulin effect on glucose transport in muscle, adipose tissue and liver. Aim of the study: The purpose of this study is to investigate the relationship between the level of serum Insulin and Homeostasis model Assessment (HOMA)-Insulin resistance levels to risk of chronic renal impairment (CRI) Materials and methods: This study include 50 patients (32 males and 18 females) who have chronic renal impairment disease with and without T2DM aged between (30-70) years, the mean age as (mean± SD) is (56.4± 10.7),(52.8±18.5) years who attended the hemodialysis (HD) at the artificial kidney in AL- Karama Hospital and 30 normal volunteers aged mach with (30-70 years)act as control. The mean age is (57±6) years .This study examined the relationship between fasting serum glucose ,insulin ,Homeostasis Model Assessment (HOMA) –Insulin resistance in CRI patients . Insulin was measured by (enzyme immunosorbant assay) . Results: Mean systolic BP and body max index BMI values were significantly higher among persons with diabetes compared with their counters without diabetes and control. Diabetic participants had higher mean levels of serum glucose, serum insulin, HbA1c and HOMAinsulin resistance compared with non diabetic participants and control. Diabetic participants also had a higher prevalence of elevated serum creatinine, urea and cholesterol level with CRI compared with their counterparts without diabetes and control . Conclusion: This study documents the presence of a strong, positive correlation between insulin resistance and chronic renal impairment among non diabetic patients .These data demonstrate that patients with chronic renal impairment have a high prevalence of IR, insulin levels .
Keywords
chronic kidney disease; Insulin resistance; diabetes

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