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The Efficacy of the Antimuscarinic Drug Oxybutynin in the Treatment Women with Overactive Bladder (OAB) Symptoms | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 12, Issue 2, 2013, Pages 282-287 PDF (0 K) | ||
| Authors | ||
| Jassim Mohammad Alkhazraji; Ban Dawood Mahmood | ||
| Abstract | ||
| ABSTRACT: INTRODUCTION: Overactive bladder is a symptom based syndrome and defined by the International Continence Society (ICS) as urgency, with or without urgency incontinence, usually with frequency and nocturia, if there is no proven infection or other obvious pathology (1) . * Department of Urology, Al-Karama Teaching Hospital; Baghdad. ** Department of Gynecology and Obstetrics, Ibn Al-Baladi Hospital; Baghdad. BACKGROUND: Overactive bladder (OAB) is a symptom based syndrome. These symptoms include: urgency, with or without urgency incontinence, usually with frequency and nocturia with no proven infection or other pathology. It is encountered in women visiting urodynamic units as part of mixed urinary incontinence (MUI). It greatly affects physical and social activities. Incontinence is often the key symptom for the assessment of OAB symptoms and the decision to treat patients. Antimuscarinic drugs are the main agents used to treat this condition. Oxybutynin (immediate-release) 5 mg orally is the main available form in our clinical practice. OBJECTIVE: The objective of this study is to assess the efficacy of Oxybutynin immediate-release (OXY-IR) 5 mg oral tablets, in the treatment of women with overactive bladder, i.e. reduction in episodes of urge incontinence, total incontinence, and micturition frequency. MATERIALS AND METHODS: Twenty-five patients, age range from 18-75 years, diagnosed as having overactive bladder symptoms were treated with Oxybutynin immediate-release (IR) 5 mg tablets 2-3 times daily for 8 weeks period. Homma OAB symptom score system was used for assessment of treatment efficacy. Cystometry was done in all patients to look for detrusor overactivity. RESULTS: After Oxybutynin treatments, all the parameters in micturition patterns improved significantly: frequency, nocturia, urgency (p value < 0.005). Homma overactive bladder symptoms scores also improved following the treatment (p value <0.001). Cystometric examination revealed the presence of detrusor overactivity in 20 of the 25 (80%) patients at presentation. This was reduced to 4/25 (16%) following treatment. About two-thirds (64%) of the patients reported good to great benefit from the treatment and had a positive effect on their life concerning physical and social activity, sleep and feeling of well-being. CONCLUSION: The selective antimuscarinic agent Oxybutynin (OXY-IR) 5 mg 2-3 times orally is effective in treating overactive bladder symptoms in these women by reducing incontinence attacks, urgency, micturition times and nocturia; consequently, it improves their life quality. We recommend devising a score system for OAB suiting Iraqi patients | ||
| Keywords | ||
| overactive bladder; OAB; urgency; incontinence; urodynamic study; oxybutynin | ||
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