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Serum CA-125 in Ectopic Pregnancy | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 12, Issue 3, 2013, Pages 343-350 PDF (0 K) | ||
| Authors | ||
| Lilyan W. Sersam; Rasha Shakir Mahmood | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: CA-125 is a glycoprotein, its origin is uncertain during pregnancy. It rises during the first trimester and returns to a non-pregnancy range in late pregnancy. OBJECTIVE: To compare CA-125 levels between tubal ectopic and normal intrauterine pregnancy, and to find it’s usefulness in differentiating intact from ruptured tubal ectopic pregnancy. METHODS: This prospective case-control study was carried out on sixty healthy women with single normal intrauterine pregnancy (NIUP) of 6-10 weeks gestation and sixty women with tubal ectopic pregnancy of same gestational age which were further subdivided into twenty-five women with ruptured tubal ectopic pregnancy (REP) and thirty-five women with unruptured tubal ectopic pregnancy (UREP). The levels of CA-125 were compared between these groups. RESULTS: The mean level of CA-125 in ruptured ectopic pregnancy group was 49.04±33.63 IU/ml and in unruptured ectopic pregnancy group was 24.3±16.89 IU/ml. The mean level of CA-125 in normal pregnant women (control group) was 53.95±31.2 IU/ml. There was a statistically significant difference between mean serum CA-125 levels of ruptured ectopic pregnancy and unruptured ectopic pregnancy group (p< 0.05), also there was a statistically significant difference between mean of CA-125 level of unruptured ectopic pregnancy group and control group (p <0.05), while there was no statistically significant difference between ruptured ectopic pregnancy group and control group (p > 0.05). CONCLUSION: CA-125 level is significantly elevated in ruptured tubal ectopic pregnancy than the intact tubal ectopic pregnancy, this increase in CA-125 levels can be used as additional test to identify tubal rupture | ||
| Keywords | ||
| level; Ectopic pregnancy | ||
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