Synthesis, Characterization and biological activity of some  oxadiazoles derivatives and thiadiazoles derivatives

Khalaf Jebur AL-Joubory, Ihmood; Albayati, Thaaer.F.Khalil; Albayati, Khalaf.A.Jasim; S, Tareq; AL-Joubory, Mahmood

	Synthesis, Characterization and biological activity of some oxadiazoles derivatives and thiadiazoles derivatives
Diyala Journal For Pure Science
Article 1, Volume 9, Issue 3, 2013, Pages 47-56
Authors
Ihmood Khalaf Jebur AL-Joubory; Thaaer.F.Khalil Albayati; Khalaf.A.Jasim Albayati; Tareq S; Mahmood AL-Joubory
Abstract
In this our research were chosen as a source number of heterocyclic compounds. Substituted hydrazide (2) was synthesized from the reaction of ester (1) with hydrazine hydrate in presence of alcohol. The ester obtained from the reactions of Para nitro benzoic acid (1) with absolute ethanol in presence concentrated sulfuric acid. The para nitro pheny hydrazide (2) was treated with carbon disulfide in ethanolic potassium hydroxide solution to give 5-pheny-1,3,4-oxadiazole-2-thiol (3). The reaction of compound (3) with hydrazine hydrate give 1, 2, 4 - triazole (5).The reaction of compound (3) with various aryl halid using KOH alcoholic to give 5-Phenyl-1,3,4-xadiazoleo thio ether (4a-e). A number of substituted -1,3,4-oxadiazole (7a-g) and substituted 1,3,4-triazoles (5). The para nitro phenyl hydrazide (2) which upon its reaction with various aldehydes aromatic or keto phenone in absolute Ethanol yield corresponding Schiff bases (6a-g). The compounds (6 a – g) were treated with acetic anhydride to give (7a– g). The synthesized compounds were identified by using the melting point and infrared spectra analysis and the result are compatible with their assigned structures.
Keywords
oxadiazole; Triazoles; biological activity

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