Expression of death receptor (Fas) , and it's specific ligand (FasL)in transitional cell carcinoma of the urinary bladder.

	Expression of death receptor (Fas) , and it's specific ligand (FasL)in transitional cell carcinoma of the urinary bladder.
journal of kerbala university
Article 1, Volume 1, Issue 0, 2005, Pages 98-105 PDF (0 K)
Abstract
This study was designed by using 36 paraffin embedded tumor tissues obtained from TCC patients, and 10 normal bladder tissues obtained from forensic medicine institute. All specimens undergone to in situ hybridization technique for in situ mRNA expression detection of Fas and Fas L ; results of this study reveled that a high significant expression in malignant tissues compaired with normal tissues (p< 0.05 ), (P > 0.05) respectively .Moreover ,FasL expression on transitional malignant cells has a linear increase with tumor grade and stage progression ; there was a significant difference in FasL expression between grade I and grade III(P < 0.05) and between stage T1 and T2 (P < 0.05) . while we found an inverse relation between Fas expression on these cells and tumor grades and stages progression ; there was a significant difference among grades and among stages (P < 0.05) , (P < 0.05) respectively. while there was no significant differences in Fas /FasL expression on lymphocytes and tumor grade and stage progression (P>0.05), (P>0.05) respectively. A highly significant liner relation was showed between Fas L expression on transitional malignant cells tumor grade and stage progression (p<0.01) , (p<0.01) respectively . From this study we conclude that overexpression of FasL are correlated with TCC invasion and progression.
Keywords
Urinary bladder; transitional cell carcinoma; Fas; Fas ligand; in situ hybridization; FasL

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