T. Ameen, S., Y. Al-Badry, S. (2005). Development of Indirect Spctrophotometric Method for the Determination of Clonazepam in pharmaceutical preparation Using Resorcinol. , 1(0), 293-302.
Suham T. Ameen; Shatha Y. Al-Badry. "Development of Indirect Spctrophotometric Method for the Determination of Clonazepam in pharmaceutical preparation Using Resorcinol". , 1, 0, 2005, 293-302.
T. Ameen, S., Y. Al-Badry, S. (2005). 'Development of Indirect Spctrophotometric Method for the Determination of Clonazepam in pharmaceutical preparation Using Resorcinol', , 1(0), pp. 293-302.
T. Ameen, S., Y. Al-Badry, S. Development of Indirect Spctrophotometric Method for the Determination of Clonazepam in pharmaceutical preparation Using Resorcinol. , 2005; 1(0): 293-302.

Development of Indirect Spctrophotometric Method for the Determination of Clonazepam in pharmaceutical preparation Using Resorcinol

journal of kerbala university
Article 1, Volume 1, Issue 0, 2005, Pages 293-302    PDF (0 K)
Authors
Suham T. Ameen; Shatha Y. Al-Badry
Abstract
This paper describes the development of a spectrophotometric method for the determination of Clonrazepam after diazotization of its reduced product and coupling with Resorcinol in basic medium , to form an intense yellow – colored , water – soluble and stable azo-dye which shows a maximum absorption at 341 nm. Beer’s law is obeyed over the concentration range 1.2 to 20 ppm with a molar absorptivity 4.5147×104 L.mol-1.cm-1 and Sandell’s sensitivity of 6.993×10-2μ g.cm-2. The relative error is ranged from -0.017 to 2.74 % and relative standard deviation from ±0.001 to ±0.2636 % , depending on the concentration level. The method has been applied successfully to the determination of Clonazepam in pharmaceutical preparation .
Keywords
Clonazepam; Resorcinol; Coupling Reagent
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