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Immunohistochemical Expression of c-Myc and p53 Proteins in Colorectal Carcinoma | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 21, Issue 2, 2010, Pages 17-26 | ||
| Author | ||
| Amal H. Salman | ||
| Abstract | ||
| The purpose of this study was to investigate the possible role of c-Myc and p53 in patients with colorectal cancer by using immunohistochemical analysis. The paraffin embedded sections from 40 colorectal carcinoma and 40 healthy individuals were investigated for the expression of c-Myc and p53 by immunohistochemical staining with specific monoclonal antibodies. Our data analysis demonstrated a significantly increased expression of c-Myc and P53 among colorectal cancer patients compared with control groups (p<0.01). In addition our results showed that in patients with colorectal cancer the positive expression rate was 80% and 62.5% for c-Myc and p53, respectively. Furthermore, in this study the significant correlations was found between these two markers (p<0.05) in two studied groups. Our results confirms a significant association between colorectal cancinoma and increased expression of c-Myc and P53. | ||
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