Susceptibility of the Members of Enterobacteriaceae Isolated from Patients with UTIs to Cephalosporins

S. Al-Nassiry, Mithaq

	Susceptibility of the Members of Enterobacteriaceae Isolated from Patients with UTIs to Cephalosporins
Al-Mustansiriyah Journal of Science
Article 1, Volume 21, Issue 1, 2010, Pages 9-18
Author
Mithaq S. Al-Nassiry
Abstract
This study was conducted at the Al-Kindy Teaching Hospital to determine the susceptibility patterns to cephalosporins of members of the family Enterobacteriaceae isolated from urinary tract infections (UTIs). A total of 270 urine specimens were collected from February, 2007 to May, 2007. From a total of 150 specimens which yielded positive growth,there were 105 isolates belonging to members of the family Enterobacteriaceae (70%). Escherichia coli was found to be the most organism (30.4%), followed by Klebsiella spp (29.5%). The results of susceptibility of isolates under study to different cephalosporins were moderately to highly resistant to many of the test agents. The results of the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) for the cephalosporins explained the high level of resistance to cephalothin and cefaclor, and a moderate level of resistance to cefotaxime, ceftazidime and cefixime. The increasing MIC of cephalosporins especially third generation indicated decreasing susceptibility of these isolates to these types of β-lactam agents due to the production of extended spectrum β-lactamases (ESBLs).

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