Balance of Vaginal System

M. Al-Khafaji, Zahra; Jaber, Khairiya

	Balance of Vaginal System
Iraqi Journal of Biotechnology
Article 1, Volume 12, Issue 1, 2013, Pages 1-21
Authors
Zahra M. Al-Khafaji; Khairiya Jaber
Abstract
In general the success of biosystem depends on its flora . Human represents superorganism as it contains variable microbial flora which called human microbiome. The latter divided into core microbiome and variable microbiome . Distribution of human microbiome concentrated in systems and organs exposed to the outer environments, such as ; skin, mouth , nose, digestive channel , urogenital channel .Vagina represents one of the secondary environment in the body responsible for reproductive health . and since it exposes to the external environment it should have some sorts of defenses . The components of vaginal defenses are: vaginal epithelial cells and its associates which excretes some defensins. Vagina has its own innate immunity, presence of IgG, IgA. In the vagina, there is some enzymes or enzyme inhibitors such as Stable serine protease inhibitor (SLPI) . In addition there are some more defense facilities such as Mannose binding lectins (MBL) , Chaperone (HSPs) which increased upon infections and inflammations , antimicrobial peptides. The main natural flora of the vagina is Lactobacilli, which classified into Lactobacillus acidophilus complex using routine rout and can be differentiated more using molecular route . These bacteria are responsible for setting the acidic reaction of the vagina . It can protects vagina against different infections and can be used to restore the unbalanced vaginal conditions if it selected carefully according to certain criteria .
Keywords
vagina; Lactobacilli; Microbiome; core microbiome; superorganism

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