Sustained Release of Fluoride from Fluoridated Muco-adhesive Oral Tablets in Saliva

J. Abdul Hassan Alsareff, Omar

	Sustained Release of Fluoride from Fluoridated Muco-adhesive Oral Tablets in Saliva
Al-Mustansiriyah Journal of Science
Article 1, Volume 21, Issue 4, 2010, Pages 41-48
Author
Omar J. Abdul Hassan Alsareff
Abstract
To prepare Muco-adhesive tablets containing sodium fluoride (2 mg), hydroxypropyl methylcellulose HPMC, Carbopol - 934, and manitol, by different ratio to obtain controlled and sustained release of fluoride in saliva from the tablet and to be evaluated in vivo. Muco-adhesive tablets have achieved by direct mixing of sodium fluoride, hydroxypropyl methylcellulose HPMC, Carbapol - 934, magnesium stearate, and manitol, then the mixture was compressed in a single-punch machine. The assays were carried out on 22 healthy adult males and females volunteers aged 35-55 years and their mean weight 65-90 kg the subject were instructed not to eat 2 hours before the administration of tablet except water. The tablet was placed on the mucous membrane of the mouth (Maxillary or mandibular labial vestibule) inside the lower lip for 8 hour. The concentration of fluoride in saliva was determined after different periods. Fluoride was estimated by the direct method. The result show that typical appearance of intact human oral mucosa was seen before and after contact with the tablet. The tablet taste was accepted by the volunteers. The percent concentration of fluoride in saliva calculated from the total amount of fluoride in the muco-adhesive tablet which containing 2 mg. There was no statistical differences between fluoride concentration in saliva individuals (P > 0.05). In conclusion, the Immediate release of fluoride from muco-adhesive fluoride tablets was over 40% of the drug in first ( 2 ) hours, There was fluoride in saliva during the 8 hours

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