Comparison Study for the Effect of Interleukin -6 and Carbimazole Drug in Rat Thyroid Gland Functions

Razaq, Shaima; I.Al-Lehibi, Khalid; N.Alwachi, Sabah

	Comparison Study for the Effect of Interleukin -6 and Carbimazole Drug in Rat Thyroid Gland Functions
Iraqi Journal of Science
Article 1, Volume 54, Issue 3, 2013, Pages 590-600
Authors
Shaima Razaq; Khalid I.Al-Lehibi; Sabah N.Alwachi
Abstract
Since the inflammatory factor IL-6 known by its critical role in different metabolic reactions in the body, therefore, this study was designed to detect it is effect in the thyroid gland function by injecting three groups of rats, the first with IL-6 , the second with carbimazole (antithyroid drug) and the third with normal saline (Control).The experiment included three groups of rat; each was injected with recombinant human interleukin-6 (rhIL-6), Carbimazole, or normal saline (Control). The results of experiments showed that both IL-6 and carbimazole caused a decrease in the levels of thyroid hormones (T3 and T4) in animal sera, and a significant decrease in animal body weight, but had no effect on the liver weight.There was a significant decrease in glucose level in the animals injected with carbimazole, while in the IL-6 treated animals there was no change in glucose level. There was a significant increase in serum level of triglyceride and very low density lipoprotein cholesterol in the animals treated with IL-6, while in the animals treated with carbimazole, there was no such change. Additionally, injection of the animals with IL-6 or carbimazole caused a significant increase in lymphocyte apoptosis of peripheral blood
Keywords
Interleukin; Thyroid gland; Carbimazol; Lipids

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