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Synthesis and Antimicrobial Activity of Some New Acetylenic Amine of Isatin Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 21, Issue 4, 2010, Pages 61-72 | ||
| Author | ||
| Suaad M. H. Al- Majidi | ||
| Abstract | ||
| In the present work, a series of some new acetylenic amines of Isatin(Indole-2,3-dione), were prepared 3-(2,3-dimethy phenyl- imino)-1H-indole-2-one [1] which was prepared by condensation Isatin with 2,3- dimethy phenyl amine in the presence of glacial acetic acid and absolute ethanol as solvent.The product was treated with sodium hydrite in DMF at 0 C to give asuspension of the sodium salt of Isatin derivative and subsequent reaction with propargy bromide to obtain, 3-(2,3-dimethy phenyl- imino)-2- oxo-1-indol-(1-prop-2-ynyl) [2]. Mannich reaction was carried out on compound [2] using paraformaldehyde and different amine, cuprous chloride as catalyst, and the compounds were obtained [3-17]. The prepared compounds were identified by spectral methods [FTIR,1H-NMR, 13C-NMR] and some of its physical properties were measured, furthermore the effects of the new compounds on four types strains of bacteria and one yeast were studied. | ||
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