Clinical Study of Obestatin Hormone and its Relation to Diabetes Mellitus

A. Allwsh, Thikra; A. Mohammad, Jehan

doi:10.33899/rjs.2013.77818

	Clinical Study of Obestatin Hormone and its Relation to Diabetes Mellitus
Rafidain Journal of Science
Article 8, Volume 24, Issue 7, 2013, Pages 74-87 PDF (0 K)
DOI: 10.33899/rjs.2013.77818
Authors
Thikra A. Allwsh; Jehan A. Mohammad
Abstract
The research included an estimation of the concentration of obestatin hormone level in diabetic patients (Type I and Type II) and control. The results demonstrated that the normal mean of obestatin hormone in serum was (306.54 ± 3.0pg/ml) in control for both sexes, with the ages range between (less or equal to 15 - more or equal to 55) year. The results demonstrated a significant decrease in the level of obestatin hormone in serum of type I and type II diabetic patients compared to control, and between types I & II diabetic patients. The data showed that the level of obestatin hormone was not affected by age and sex, in control and diabetic patients, while showed a significant decrease according to body mass index (BMI) in control and diabetic patients (Type I and II). A significant gradual decrease in the concentration of obestatin as glucose concentration increases in diabetic patients was also observed. The results showed a significant increase of adiponectin concentration between type I diabetic patient compared to type II, control, and a significant decrease in the concentration of adiponectin in diabetic patients (type II) compared with control. Correlation coefficients of obestatin hormone with some biochemical parameters of control and diabetic patients showed that obestatin hormone has a significant negative correlation with glucose, HOMA-IR, total cholesterol and LDL-C. Also, there was a significant positive correlation with HDL-C and adiponectin in control and diabetic patients (type I and II). The result showed that obestatin hormone has a significant negative correlation with insulin, VLDL-C, total lipids in type II diabetic patients. Also, with triglyceride in control and type II diabetic patient. It was concluded that low level of obestatin hormone index is a serious risk of diabetes mellitus and a major role for obestatin in diabetes mellitus type II. Moreover, the level could be used as a marker for diabetes mellitus and its role in obesity.
Keywords
Obestatin hormone; adeponectin hormone; diabetes; biochemical parameters; insulin resistance

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