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Simultaneous Determination of Chlorpromazine and Trifluo- perazine in Pharmaceutical Preparations Using High Performance Liquid Chromatography | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 2, 2011, Pages 123-128 | ||
| Author | ||
| Jameel M. Dhabab | ||
| Abstract | ||
| Reversed phase high performance liquid chromatography (RP- HPLC) was used for the simultaneous determination of chlorpromazine and trifluoperazine in pharmaceutical preparations, with a mobile phase of cyclohexane: methanol: dimethylamine (5:1:1) volume ratio at 1.5 ml.min-1 flow rate to separate both compounds by detection at 254 nm. This method gave the best resolution of chlorpromazine and trifluoperazine at retention times of 7.18 and 9.62 minutes, respectively. Linearity was obtained in the concentration range of 0.02-20µg ml-1for chlorpromazine and 0.05-20 µg mL-1 for trifluoperazine. The obtained results were highly accurate (Rec.,98.6%-98.8%) and good precise (RSD, 1.19%–1.95%). The described method showed to be appropriate for simultaneous determination of chlorpromazine and trifluoperazine in pharmaceutical dosage forms. | ||
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