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Synthesis of Some New Heterocyclic Compounds Using - (N-Saccharin) Acetohydrazide | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 0, Issue 50, 2014, Pages 199-206 | ||
| Author | ||
| Ahmed Wahed Naser | ||
| Abstract | ||
| Abstract Different new compounds derived from - (N-saccharin) acetohydrazide (1) as starting material were synthesized. The Schiff bases (2a, b) were obtained by condensation of (1) with 2,4-dimethoxybenzaldehyde and p-dimethylaminobenzaldehyde, The cyclization of (2a, b) with maleic anhydride, phthalic anhydride, glycine, alanine and chloroacetyl chloride gave the corresponding oxazepine, (3,4a, b), imidazolidine (5a-d) and azitidine (6 a,b) derivatives. . Reaction (1) with ammonium thiocyanate gave triazol derivative (7). Compound (7) that cyclized either with chloroacetic acid in presence sodium acetate or a mixture of chloroacetic acid and 2,4-dimethoxybenzaldehyde or p-dimethylaminobenzaldehyde to give the corresponding derivatives (8) and (9 a,b). IR, elemental analysis, 1HNMR and 13C-NMR were used to characterize the target compounds | ||
| Keywords | ||
| saccharin; oxazepine; imidazolidine; azitidine; Triazol | ||
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