Study of some biochemical and immunological parameters in Iraqi benign prostatic hyperplasia and lower urinary tract symptoms patients

Saadi Saleh, Eman; Muthana Yousif, Mohammed; Hamada Ali, Amal

	Study of some biochemical and immunological parameters in Iraqi benign prostatic hyperplasia and lower urinary tract symptoms patients
karbala journal of pharmaceutical sciences
Article 1, Volume 4, Issue 5, 2013, Pages 24-33 PDF (0 K)
Authors
eman saadi saleh; mohammed muthana yousif; amal hamada ali
Abstract
Benign prostatic hyperplasia (BPH) alone or with lower urinary tract symptoms (LUTS) was of the major public health problem among men especially over 55. In this trial serum interleukins six& eight (6&8) were estimated, also determining renal function test (urea& creatinine) and uric acid. Highly sensitive C- reactive protein (hs- CRP) and total prostate specific antigen (t- PSA) were measured in BPH, BPH+ LUTS and control groups. The result of this trial illustrate the elevation of all biochemical & immunological parameters significantly in both A&B groups when compared with control (P value= 0.002, 0.001 &0.000) except uric acid in group A appear insignificantly increased with group C (P value=0.477). In conclusion the study predict the increasing in selected parameters very well & clearly so this help in diagnosis and management of BPH alone or with LUTS accompanies with inflammation which play an important role to transfer the benign disease to malignant. The aim of this study is to evaluate some clinical parameters especially hs- CRP that not previous used as a marker in the blood of elderly individuals who suffered from BPH with or without LUTS be of assistance in diagnosing & managing once in order to decrease the complication and severity of patient status which may convert the benign to malignant cases.
Keywords
Benign prostate hyperplasia; lower urinary tract symptoms Interleukin; CRP; PSA; renal function test

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