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Synthesis of Some Pyrimidine Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 2, 2009, Pages 47-58 | ||
| Author | ||
| Redha I. Al-Bayati | ||
| Abstract | ||
| In this work, ethyl 4-(4-chloro phenyl)-6-methyl-2-oxo-l ,2,3,4-tetrahydro pyrimidine-5-carboxylatc (1) was prepared from condensation of 4-chloro benzaldehyde, urea with ethyl acetoacctate in the presence of LaCl.7H2O and then converted into the carbohydrazide (2). The azomethines (3-11) were prepared from the corresponding aryl aldehydes or ketones with the carbohydrazide derivative (2). The reactions of some new Schiff bases (3-11) with anhydrous acetic acid and mercapto acetic acid afforded 5-(4-acetyl-5-aryl-4,5-dihydro-l,3,4-oxadiazol-2-yl)- 4-(4-chloro phenyl)-6-methyl-3, 4-dihydro pyrimidine-[lH]-2-ones (12-15) and 4- (4-chloro phenyl)-6-methyl-2-oxo-N- (4-oxo-2-aryl-l,3- thiazolidin-3-yl)-1,2,3,4- tetrahydro pyrimidine-5-carboxamide (16-18) respectively.The synthesized compounds were confirmed by IR and UV spectral data | ||
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