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Synthesis and Antimicrobial of (C7) Fused Riny (Thio or dithio ) Substituted Cephalosporins | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 2, 2009, Pages 18-29 | ||
| Author | ||
| Redha I.Al-Bayati | ||
| Abstract | ||
| New hetrocyclic derivatives of 7- aminocephalosporinic acid comprisiry 7-[2-(6- aryl-5-arylimino-5,6-dihydroimidazo[2,1-b]-1,3,4-thiadiazol-2-yl) thioacetamido and dithio acetomido moieties are reported. Oxidation of 2-mercapto-6-aryl- 5- arylimino-5, 6-dihydro imidazo[2,1-b]-1,3,4-thiadiazoles(1-5)by H2O2 resulted 2,2- dithio bis(6-aryl-5-arylimino- 5,6-dihydroimidazo[2,l-b0-l,3,4- thiadiazoles (6-10) and then converted into dithio acetic acid derivatives (11-15). The acid chlorides of compounds (11-15) were prepared from their reactions with thionyl chloride - triethyl amine, which upon stirring with amino cephalosporinic acid (7-ADCA) at room temp yielded the corresponding cephalosporins (16-20). On other hand, compounds (1-5) were converted into thioacetic acid derivatives (21-25) by reaction with chloroacetic acid in alkaline medium , which upon following same steps as for preparation of (16-20) yielded the corresponding cephalosporins (26-30). Furthermore, the antimicrobial activities against both Gram-positive and Gramnegative bacteria were evaluated for the synthesized of compounds | ||
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