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Synthesis and Antimicrobial Activity Study of Several New Tetrachlorophthalimides Substituted With Different Heterocycles | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 4, Issue 5, 2013, Pages 131-148 PDF (0 K) | ||
| Authors | ||
| Ahlam Marouf Al-Azzawi; Kafa Khalaf Hammud | ||
| Abstract | ||
| A series of new tetrachlorophthalimides linked to different Heterocycles including (thiazole, benzothiazole, thiadiazole, pyridine, and quinoline) were synthesized and followed by their antibacterial and antifungal screening. The synthesis of the new imides was performed via two steps, the first one involved preparation of a series of N-substituted- tetrachlorophthalamic acids via reaction of tetrachlorophthalic anhydride with different heterocyclic primary amines. Dehydration of the prepared tetrachlorophthalamic acids by treatment with acetic anhydride and anhydrous sodium acetate in the second step afforded a series of the desired N-substituted- tetrachlorophalimides. Biological activities of the prepared imides were evaluated and the results showed that these compounds have good biological activity. | ||
| Keywords | ||
| Thiazole; benzothiazole; thiadiazole; pyridine; and quinoline | ||
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