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Synthesis of New Cephalosporin Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 3, 2009, Pages 8-18 | ||
| Author | ||
| Redha I.Al-Bayati | ||
| Abstract | ||
| 7-[2-(l-Arylidene amino)-l,3,4-thiadiazole-5-yl]-dithioacetamido]-cephalosporanic acids (17-21) and 7- [2-(2-(1-arylidene amino) -1,3,4-thiadiazole 5-yl)- thioacetomido ]-cephalosporanic acids (27-31) were obtained through the reactions 7- amino cephalorosporanic acid with acyl chlorides derivatives of 2-[2-(l-arylidene amino)-1,3,4- thiadiazole-5-yl] dithioacetic acids (12-16) and 2-[2-(1-arylidene amino)-1,3,4-thiadiazole-5-yl] thioacetic acid (22-26) respectively .compounds (21-16) was prepared by the oxidation of Schiff's bases (2-6) with H202, then the reactions of disulfide compounds (7-11) with thialats amino of mercapto acetic acid. While compounds (22-26) were prepared by the mixed anhydrous method using thionyl chloride. Further more , the antimicrobial activity of these synthesized compounds were evaluated by using representative strains of gram ^positive and gram- negative bacteria. The synthesized compounds were verified by their IR , UV , 'HNMR and C.H.N, data. | ||
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