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Controlled Release of Propanolol Hydrochloride Drug from Cyanoethylstarch Hydrogel | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 3, 2009, Pages 41-52 | ||
| Author | ||
| Zahraa A. M. Al-Witry | ||
| Abstract | ||
| Cyanoethylation of starch has been carried out by the reaction of starch with acrylonitrile in basic medium. The prepared polymer has been characterized by IR spectroscopy. The gelation of raw material (starch) and modified Starch (cyanoethylstarch) according to the equilibrium %swelling degree has been investigated in different media (distilled water, n-saline and buffer solution PH=2).Cyanoethylstarch (CES) shows higher uptake of water compared with starch, suggests more hydrophilicity. In vitro Controlled release of (PHCl : Propanolol hydrochloride) drug from (CES) hydrogel were studied in three different media (distilled water, n-saline and buffer solution PH=2) using ultra violate absorption follow quantities released at different times.The concentrations of drug released increased gradually and then attain affixed value at certain drug load. | ||
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