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Synthesis of New C-Substituted Phenothiazine Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 3, 2009, Pages 30-40 | ||
| Author | ||
| Suad M. Al.Araji | ||
| Abstract | ||
| The aim of the present work is synthesis of new phenothiazine derivatives containing C-substituted phenothiazine starting from phenothiazine. Synthesis of (3,7-disulfonyl phosphineimine) 10H phenothiazine (5-8) through the reaction of phenothiazine with acetyl chloride and acetic anhydride to give compound (2), which react with chloro sulfonic acid to give (3,7-disulfonyl chloride)10H- phenothiazine (3) then react with sodium azide to give (3,7-disulfonyl azide)10H- phenothiazine (4). Condensation of compound (4) with triphenyl phosphine, triphenyl phosphite, trimethylphosphite, and dimethyl phenyl phosphine gave the (3,7-disulfonyl phosphineimine) 10H-phenothiazine (5-8) The biological activity of number of the prepared compounds were tested against two types of bacteria Eschericha coli and staphyllococous aureus. | ||
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