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Spectrophotometric Determination of Amoxicillin-Application to Capsules | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 4, 2009, Pages 35-42 | ||
| Author | ||
| Jwan A. Abdul-Sattar | ||
| Abstract | ||
| In this study, a novel spectrophotometric method is given for the determination of amoxicillin in its pharmaceutical dosage form. The method is based on the preparation of 6-[α-(4-hydroxy phenyl)-α-(4-Bromo benzelidiene)]acetamido-pencillinic acid from the reaction of 6-[α-(4-hydroxy phenyl)-amino]acetamido pencillic acid (amoxicillin) with (4-bromobenzaldehyde)as a chromogenic reagent in absolute ethanol. Linearity was in the range (9-350) µg.ml-1 with a limit of detection (0.14) µg.ml-1for the drug. Linear response was observed over the tested range of the drug with correlation coefficient (0.9997).The mean relative standard deviation percentage (RSD=0.49%) which confirmed the reproducibility of the assay technique. The method showed insignificant difference with those of reference methods. The method was applied successfully to the determination of amoxicillin in its dosage form. | ||
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