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Synthesis and Biological Activity of Some New 2-(4́-Hydroxyphenyl)-5-[4́-(4˝-alkoxybenzylidene) amino phenyl]-1,3,4-oxadiazole Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 20, Issue 4, 2009, Pages 43-53 | ||
| Author | ||
| Ali H. Rhayma | ||
| Abstract | ||
| New series of ester compounds containing 1,3,4–oxadiazole unit have been synthesized from the condensation of 2-(4-hydroxy phenyl)-5-[4(4-n-alkoxy benzylideneamino)Phenyl]-1,3,4-oxadiazole with valeroyl chloride in dry DMF and in the presence of Et3N The structures of the products were charecterized through their physical properties and by spectroscopic methods. The biological activity of prepared compounds have been studied against two types of bacteria ( E.Coli and S.Aureus) . All the compounds show a good antibacterial activity towards E.coli , but no any activity has been observed againsty against S.Aureus . The biological activity of these compounds show a slight increase as the number of carbon atoms in the alkoxy group (OR). | ||
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