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Expression of Anti Apoptotic Gene in Exophytic and Endophytic Type of Oral Carcinoma | ||
| Kerbala Journal of Medicine | ||
| Article 8, Volume 3, Issue 6, 2010, Pages 812-821 PDF (0 K) | ||
| Author | ||
| Header Dakhel Al- muala | ||
| Abstract | ||
| background: Bcl2 is known to belong to a family of apoptosis regulatory gene products that may be death antagonist eg (bcl- 2, bcl-xl , mcl –l) or death agonist ex (bax , bak , bcl -xs , bad) , The bcl- 2 oncoprotein inhibits apoptosis and is expressed by many tumors including carcinoma such as breast ,cervix and head and neck . Aims to identify bcl-2 oncogene product expression of oral carcinoma and its correlation to clinical features (exophytic , endophytic and mixed type) of oral carcinoma Patients and methods Twenty four patients were gathered , 20 patients had squamous cell carcinoma and four patients with adenoid cystic carcinoma . Paraffin blocks were obtained of the study group , specimens of follicular lymphoma paraffin blocks were obtained from pathology department at teaching laboratory of medical city . Normal oral mucosa were obtained from healthy patients who had undergone routine oral surgery following informed consent of the patients . Immunohistochemical procedure of Bcl2 protein were applied . Results our study showed that 11 cases of the exophytic type of oral carcinoma represented a positive bcl2 expression , 4 cases of the endophytic (ulcerative type) showed a positive immunoreactivity with bcl2 antibodies and 3 cases of mixed type (exophytic type and endophytic) showed a positive bcl2 expression . Statistical analysis showed non significant relationship between clinical features (exophytic , endophytic , Mixed type) and bcl2 expression in oral carcinoma . Conclusion :- bcl-2 expression in normal oral mucosa and oral carcinoma ,bcl-2 immunoreactivity was more correlated to mixed type , exophytic and rarely to endophytic oral carcinoma but all didn't reach a statistical significance . Keywords ,anti apoptotic gene product , bcl2 expression , oral carcinoma. | ||
| Keywords | ||
| anti apoptotic gene product; bcl; oral carcinoma | ||
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