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Synthesis, Evaluation Antimicrobial Activity of Some New N-substituted Naphthalimides Containing Different Heterocyclic Rings | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 54, Issue 4, 2013, Pages 761-774 | ||
| Authors | ||
| Mohammed R. Ahmad; Suaad M. H. Al-Majidi; Ayad Kareem Khan | ||
| Abstract | ||
| A series of new 1,8-naphthalimides linked to azetidinone, thiazolidinone or tetrazole moieties were synthesized. N-ester-1,8-naphthalimide (1) was obtained by direct imidation of 1,8-naphthalic anhydride with ethylglycinate. Compound (1) was treated with hydrazine hydrate in absolute ethanol to give N-acetohydrazide-1,8-naphthalimide (2). The hydrazine derivative (2) was used to obtain new Schiff bases (3-7). Three routes with different reagents were used for the cyclization of the prepared Schiff bases. Fifteen cyclic Schiff bases (8-22) with four- and five-membered rings were obtained. The structures of the newly synthesized compounds were identified by their FTIR, 1H-NMR, 13C-NMR spectral data and some physical properties. Furthermore, these compounds were screened in three concentration for their in vitro antimicrobial activity measurements against both Gram (+ve) such as Staphylococcus aureus, Bacillus and Gram (-ve) Escherichia Coli, pseudomonas aeuroginosa bacteria and against Candida albicans fungal and they were found to exhibit good to moderate antimicrobial activities. | ||
| Keywords | ||
| naphthalimides; azetidine; One; thiazolidine; Tetrazole; synthesis; antimicrobial activity | ||
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