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Chromosomal analysis and maternal age risk in some Down syndrome patients | ||
| Iraqi Journal of Biotechnology | ||
| Article 1, Volume 12, Issue 2, 2013, Pages 114-124 | ||
| Authors | ||
| Abdul Hussein Moyet AlFaisal; Rukea Geath | ||
| Abstract | ||
| Abstract: Chromosomal analysis was done on 50 clinically diagnosed Down syndrome patients. The karyotype analysis revealed that 88% (44 of 50 cases) with trisomy 21, having three copies of chromosome 21. In 2% (one case) translocation was observed, one copy of chromosome 21 was translocated to another chromosome 21 and in 10% (5 cases) there was a mosaicism for a trisomic. The higher percentage (72%) of cases was found between 21-34 years. 26% of cases were found with ages above 35 years. Only 2% of cases were found with maternal age between18-20 years and Down syndrome is more frequent in males than in females. | ||
| Keywords | ||
| down syndrome; aneuploidy; trisomy; translocation | ||
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