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The influence of different concentrations of aqueous green tea extract on methotrexate induced haematological toxicity in rats | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 13, Issue 1, 2013, Pages 105-110 | ||
| Author | ||
| Farah Kais Abdul-Wahab | ||
| Abstract | ||
| Abstract: Methotrexate (MTX), a folic acid antagonist is widely used for the treatment of a variety of tumors. In the present study, the possible protective effect of aqueous green tea extract (AGTE) in methotrexate-induced haematotoxicity was investigated. Four main groups of white Albino rats were used: control group, (MTX) group, following a single dose of MTX (20 mg/kg, i.p.) saline was administered for 5 days. (AGTE) group, was treated with 1.25% concentration of AGTE only for 12 days and the (MTX+AGTE) group, in this group rats received different concentrations of AGTE (0.625, 1.25 and 2.5%), as their sole source of drinking water, 7days before and 5 days after MTX treatment. MTX induced significant decreases in RBC, Hb, Hct, WBC and platelets. Whereas increased MCV and MCH. Moreover, the concentrations of AGTE play a major role. The best protective effects of AGTE treatment were observed at the concentration 1.25% While 0.625% and 2.5% AGTE had no protective effects on haematological parameters. Keywords: Methotrexate; haematotoxicity; Aqueous Green tea extract. | ||
| Keywords | ||
| KEYWORDS; Haematotoxicity; Aqueous Green tea extract | ||
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