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Observations on the ultrastructure of a rat mammary gland treated with harmal and borage | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 49, Issue 1, 2007, Pages 151-156 | ||
| Authors | ||
| Salim R. Hamoudi; Shatha M. Al-Faisaly; Wasan Al- Saidi; ; Malak A. Al- Yawer | ||
| Abstract | ||
| Background : It had been indentified by histological, histochemical and morphometrical studies that peganum harmala is a mammogenic herb and borage officinalis is a lactogenic one . To complete our investigation about these two herbs , we performed electron microscopical study . Materials and methods : Rats were grouped according to their physiological status into three groups . Each group was subdivided in to three subgroups : one control and two experimental . The two experimental group were treated daily; the 1st one with an aqueous extract of peganum harmala seeds and the 2nd with an aqueous extract of borage officinalis flowers . After two weeks of treatment , mammary glands were employed for electron microscopical study . Results : In virgin rats , the epithelial and myoepithelial cells were partially differentiated when harmal was given and completely differentiated when borage was given . In pregnant rats , harmal and borage optimize mammary parenchymal growth and induce lactation when these herbs were given. In lactating rats ,these herbs exhibited a picture similar to control lactating group but the budding of lipid droplets and the swelling of secretary vesicles were markedly increased . Conclusion: Both harmal and borage stimulate the release of prolactin and induce galactogenesis during pregnancy and promote it during lactation . Key Words : Mammary gland , Electron microscope , Harmal , Borage | ||
| Keywords | ||
| ammary gland; electron microscope; Harmal; Borage | ||
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