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Vitamin C, an Antioxidant Attenuates Gentamicin-Induced Acute Kidney Injury in Female Albino Wister Rats | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 10, Issue 3, 2013, Pages 656-661 | ||
| Author | ||
| Ali Abdil Razzaq Aldallal | ||
| Abstract | ||
| We investigated the effect of vitamin C against acute kidney injury(AKI) in female Albino Wister rats. AKI was produced by gentamicin as a simple method for induction AKI, so this achieved by injection of gentamicin as single dose [100mg/kg intra peritoneal (I.P) a day for 10 days] in rats. Vitamin C (200mg/kg I.P a day) was administered 1hr before AKI induction by gentamicin for 10 days. The blood urea nitrogen(BUN), serum creatinine(Scr) concentrations and Malondialdehyde (MDA) level were markedly elevated in gentamicin-AKI group after treatment 78.05±0.591mg/dl, 1.169±0.017 mg/dl and 85.70±0.587mg/dl (P<0.0001) respectively, but these elevations were significantly suppressed by vitamin C in vitamin C–treated AKI group17.81±0.457mg/dl, 0.724±0.009 mg/dl and 50.30±0.213 nmol/g (P<0.0001) respectively. These findings suggest that vitamin C can protect the renal damage caused by gentamicin. | ||
| Keywords | ||
| AKI; Gentamicin; vitamin C | ||
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