Assessment of Renal Function in Type 2 Diabetic Patients by Measurement of Serum Cystatin C in Al- Hilla City

Abid-Allah Saee, Jabbar; H. Alshlah, Haydar; S. Alawad, Alaa

	Assessment of Renal Function in Type 2 Diabetic Patients by Measurement of Serum Cystatin C in Al- Hilla City
Medical Journal of Babylon
Article 1, Volume 10, Issue 3, 2013, Pages 718-725
Authors
Jabbar Abid-Allah Saee; Haydar H. Alshlah; Alaa S. Alawad
Abstract
This study was intended to evaluate the performance of serum cystatin C and its equations for the estimation of glomerular filteration rate in comparison with serum creatinine and its equations . A total of 62 diabetic patients and 21 apparently healthy subjects as a control group were assessed. The tests done were; urine analysis , serum cystatin C , serum creatinine , HbA1c , ,and serum glucose. The weight , height and blood pressure were measured for all subjects . The results of this study showed a significant differences in the serum cystatin C level of the patients group (1.11±0.25mg/l , p < 0.01 ) as compared with its level in the controls group (0.76±0.08mg/l, P<0.01). Similarly there were a significant differences in the serum levels of glucose (224±61.9 mg/dl) , , HbA1c ( 9.6±2.1%) and creatinine (1.01±0.31mg/dl )( p< 0.01 )of the patients group as compared with that of controls group: (106.57 ±19.17mg/dl), (6.13%±2.7%), ( 0.76±0.66mg/dl) (p<0.01)respectively. There were a very strong negative correlations in the patients group between serum cystatin C and estimated GFRcyst+creat (r= -0.929, p< 0.01) , while the results for serum creatinine were :(r=-0.798 p<0.01) . The results of this study showed superiority of serum cystatin C and its equations over serum creatinine and its equations in detecting early decline in GFR.
Keywords
Diabetes Mellitus; Glomerular Filteration Rate; Cystatin C; creatinine

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