EXPRESSION OF P53 PROTEIN IN NEOPLASTIC AND NON NEOPLASTIC OVARIAN LESIONS

M. Mahmood, Fahem; S. Kadhim, Haider; R. Al Khuzaee, Liqaa

	EXPRESSION OF P53 PROTEIN IN NEOPLASTIC AND NON NEOPLASTIC OVARIAN LESIONS
IRAQI JOURNAL OF MEDICAL SCIENCES
Article 1, Volume 11, Issue 3, 2013, Pages 280-284
Authors
Fahem M. Mahmood; Haider S. Kadhim; Liqaa R. Al Khuzaee
Abstract
Background:Ovarian cancer is one of the most common causes of gynecologic neoplasm all over the world. Objective:The objective is to shed light on the role of p53 protein and patient`s age in the pathogenesis of ovarian lesions. Methods:Paraffin embedded blocks of 62 patients with ovarian lesions were studied. Thirty-five cases of surface epithelial ovarian tumors, (31 cases of invasive surface epithelial ovarian tumors, and 4 cases of borderline intermediate malignancy cases of neoplastic ovarian cystic lesions). In addition, eighteen cases of benign neoplastic ovarian cystic lesions and 9 cases of non- neoplastic functional one were enrolled in this study. All of cases included, were stained with p53 by immunohistochemistry. Results:Immunohistochemistry for p53 showed that malignant cases were positive for p53 while all benign cases were negative for p53 and the borderline cases were also negative for p53. The non-neoplastic cases were negative for p53. There is a significant statistical difference in P53 expression in malignant cases compared to other groups (P < 0.001). A significant difference in mean age of malignant and border line cases in comparison with benign and non-neoplastic cases; (P < 0.001). Conclusion:Protein p53 may play a role in the pathogenesis of malignant ovarian cancer but not in benign lesions. The age of the patient has a role as a risk factor in ovarian lesions. Keywords:Ovarian lesion, ovarian cancer, p53, immunohistochemistry.
Keywords
Ovarian lesion; ovarian cancer; Immunohistochemistry

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