Study The Effect Of Excessive Consumption  Of Alcoholic And Aquatic Extract Of Peganum Harmala On Liver And Spleen Tissue Of Male Albino Mice

Fouad  Abdulameer, Sura

	Study The Effect Of Excessive Consumption Of Alcoholic And Aquatic Extract Of Peganum Harmala On Liver And Spleen Tissue Of Male Albino Mice
Journal of University of Babylon
Article 1, Volume 21, Issue 3, 2013, Pages 927-933
Author
Sura Fouad Abdulameer
Abstract
Peganum harmala is one of most highly used medicinal plants , therefore we designed this study to investigate the histological effect of Peganum harmala on liver and spleen tissue. For this purpose, twenty five male's Swiss albino mice were divided into five equal groups, each group contains five mice. The groups of aqueous and alcoholic extract of Peganum harmala were injected by (100, 50 mg/ml) and the fifth group considered as control. After Twenty four hour then the animals scarified to investigate the histological change on liver and spleen. The result of histopathology of liver in mice that treated with 50 mg/ml aquatic extract of Peganum harmala showed double nuclei hepatocyte, And a sectional view of liver of male mice that treated with 100 mg/ml aquatic extract of Peganum harmala showed congestion of central veins and multicoagglutive necrosis characterized by nuclear change (pyknosis) together with aggregation mononuclear cells (MNCs) mainly macrophage and lymphocyte in liver parenchyma, A sectional view of liver 50 mg/ml alcoholic extract of Peganum harmala showed aggregation of inflammation cells mainly neutrophil and lymphocyte, also liver section of 100 mg/ml alcoholic extract of Peganum harmala showed aggregation of inflammation cells mainly neutrophil and lymphocyte, congestion to the central vein. While the histo-pathological change of the spleen at 50 mg/ml aquatic extract of Peganum harmala showed disposition of amyloid like substance around the white pulp, A sectional view of spleen 100 mg/ml aquatic extract of Peganum harmala showed disposition of amyloid like substance around the white pulp which lead to depletion of white pulp. while spleen sections of mice injected with 50 mg/ml alcoholic extract of Peganum harmala showed sever congestion of the red pulp, A sectional view of spleen 100 mg/ml alcoholic extract of Peganum harmala observed sever congestion of the red pulp and sever amyloid deposition of the red pulp. So the high consumption of peganum had harmful effect on liver and spleen tissue.

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