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Study The Effects Of Methotrexate (MTX) On Some Parameters Of Sperms And Histopathological Changes Of Testis Mice | ||
| Journal of University of Babylon | ||
| Article 1, Volume 21, Issue 3, 2013, Pages 1058-1064 | ||
| Author | ||
| Hazim I. A. Al-Ahmed | ||
| Abstract | ||
| Methotrexate commonly used to treat cancer and caused reproductive damage in mice , an early sign of which is sloughing of germ cells with associated sertoli cell fragments. In this study, the effects of methotrexate on some parameters of sperms and histopathological on mice testis after 35 days of MTX administration intraperitoneally (ip). Twenty-four adult male mice were divided into one control and two treated groups composed of 8 mice in each group. Treated groups received methotrexate in two different doses i.e 25 μg and 50 μg, whereas control one received normal saline intraperitoneally, the results showed significant (P<0.05) decreased in sperms motility , increased percentage of dead sperms and abnormalities of sperms in mice treated with MTX, while the results showed significant decreased in diameters of seminiferous tubules, primary spermatocytes and spermatids, increased interstitial spaces in treated groups as well as distortion of morphology of leydig cells in treated mice. | ||
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