- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Lethal Dose (LD50 )And Acute Toxicity , Histopathological Effects Of Glycosides Extract Of Lawsonia Inermis (Henna) Leaves In Mice | ||
| Journal of University of Babylon | ||
| Article 1, Volume 21, Issue 3, 2013, Pages 1093-1101 | ||
| Author | ||
| Sadiyha Yasir AL-Jubory | ||
| Abstract | ||
| This study was curried out on the extraction glycosides constituents of Lawsonia inermis leaves ,determination LD50 and study histopathological effects of intestine, lungs ,liver and kidney in mice. The results exhibited high acute toxicity with LD50 of 2116.6 mg/kg upon intraperitoneal administration in mice. The histopathological examination indicated that the tested extract induced several histopathological changes in the mice such as necrosis associated with inflammatory cell infiltration in intestinal , hemorrhage in the lungs , necrosis and desquamation in intestine , necrosis of some hepatocytes, hydropic degeneration, edema , there are scattered bile canaliculi and damage in septa between lobes of liver . Necrosis of some of renal tubules with atrophy in some other , as well as necrosis of glomerulus with dilatation of bowman’s capsule, sloughing of epithelium lining of collecting tubules , as well as presence of completely fibrosis glomerulus . | ||
|
Statistics Article View: 153 PDF Download: 77 |
||