- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Study of photolysis on the active material Phenylbutazone in veterinarian drug Isophen | ||
| Journal of University of Anbar for Pure Science | ||
| Article 22, Volume 6, Issue 3, 2012, Pages 75-78 PDF (507.96 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2012.80690 | ||
| Authors | ||
| Hanan H. Flaeh; Wajeeh Y. Mohammed; Authman S. Ibrahim; Sattar S. Ibrahim | ||
| University of Anbar - College of Science. | ||
| Abstract | ||
| The veterinary medicine isophen was used in this study. Isophen contains phenylbutazone as active material .Numbers of samples of isophen were prepared and were determined absorbance were determined and comparison subjected to radiation for different periods (1 ,2, 3, 4, 5) hrs. the Maximum absorbance were determined and compression Maximum absorbance's Study are performed. And ensure that the impact of irradiation on the active ingredient in the medication. The results reveal that has been reached that there is significant impact of irradiation as well as the time of irradiation on the decomposition of the active ingredient in the medication was found that with the continuation of the time of irradiation increases decomposition. | ||
| Keywords | ||
| Isophen; Phenylbutazone; photolysis | ||
| References | ||
|
1-Less, P., Ayliffe, T. Maitho, T.E., 1988. Pharmacokinetics, metabolism and excretion of phenylbutazon in cattle following intraveneous, intramuscular and oral admistration .Research in veterinary science in veterinary science :44:57-67 .
2- Gonzalez Martin M.I., Sanchez Gonzalez C.I., Jimenez Hernandez A., Garcia Cachan M.D., Castro de Cabo M.J., Garzon Cuadrado A.L,.2002, Determination by highperformance liquid chromatography of phenylbutazone in samples of plasma from fighting bulls. J Chromatography, 769, 119-126.
3-Less, P. and May, S.A. 1992, chapter 56 : inflammation and anti-inflammatory druges P: 843-851,in boving medice :diseases and husbandry of Catte. Ed.A.H.Andrews . Black well Scientific pulications. London.
4-Katzying BG, 1995 editor . Basic and clinical Pharmacology 6th . Norwalk Connecticut : Apleton and Lang.
5-Williams RJ, smith JA ,Boudinot F,1990, pharmacokinetics of phenyl butazon in mature Holstein bulls: steady–state kinetics After multiple oral and dosing , Am J.Vet.: 51 (3) : 367- 37o .
6-Grippa E. Santini L ., Castellano G., Gatto M. T. , Leon M.G., Saso L.,2000 Simultaneous ,determination of hydro cortisone dexamaethason indomethacin; phenylbutazon and oxyphenlbutazon in equine serum by high performance liquid chromatography. J. Chromatography B (2000) ,738 ,pp 17 – 25 .
7- Gowik P., Jülicher B., Uchlig S.,1998, Multi-residue method for non-steroidal anti-inflammatory drugs in plasm using high performance liquid chromatography–photodiode array detection. Method description and comprehensive in-house validation. J.Chromatography B,(1998)716,221-232.
8-Marnet,L.J., Dix.T.A., Sachs, R.J.,and Siedlik , P. H., (1983), in advances in prostaglandin. Thromboxane, and Leukotriene. Research (Samuelsson ,B paoletti,R and, Ramwell ,p )Vol. 11, pp: 79-86, Raven press , New York
9- Siedlik.P.H. and Marrnet, L.J.,(1984), Methods Enzymol, in press
10-Marrnet,L.J., Siedlik, P. H.,and Fung,L.W.M., (1982 ), J. Biol.chem., 257, pp: 6975-6964.
11-Marnet,L.J., Dix.T.A., Sachs, R.J.,and Siedlik , P. H., (1983), advances prostaglandins. Thromboxane, and Leukotriene. Vol. 6, pp: 149-151, Raven press , New York. | ||
|
Statistics Article View: 441 PDF Download: 302 |
||