Correlation between Glucose-6-Phosphate Dehydrogenase Deficiency and Total Serum Bilirubin Level in Children

Ahmed Chiad, Shraq

	Correlation between Glucose-6-Phosphate Dehydrogenase Deficiency and Total Serum Bilirubin Level in Children
Al-Mustansiriyah Journal of Science
Article 1, Volume 24, Issue 4, 2013, Pages 1-8
Author
shraq Ahmed Chiad
Abstract
Glucose-6-Phosphate dehydrogenase (G6PD) deficiency is the most important disease of the hexose monophosphate pathway. Deficiency of this enzyme can lead to hemolysis of red blood cells. Our aim study was determination of prevalence epidemiological features of G6PD-deficinecy in children with total serum bilirubin levels. This prospective descriptive study has been done on 300 children who were admitted with the symptoms and signs of G6PD-deficinecy to the Welfare Hospital for children in BaghdadIraq, during April 2010 to October 2012. 5172 children laboratory investigation included determination of direct and indirect serum bilirubin concentration, blood group typing, hemoglobin level, blood smear, reticulocyte count and G6PD level. We divided these children to 3 groups based on total serum bilirubin level (TSB). Our data have shown that 300 (5.8%) of 5172 children with the chief complain of G6PD-deficinecy and high male to female ratio (71% to 29%). The mean hemoglobin levels for male and female children were 84.4 ± 3.2 and 81.3 ± 6.3 fl respectively for mean corpuscular volume, and 261 (87%) children positive G6PD-deficinecy with Hb < 14mgdl, the differs signicantly (p ≤ 0.001). From 2600 hyperbilirubinemia children 1214 cases belonged to group 1 (TSB < 20mg %), 900 cases belonged to group 2 (TSB= 20-25mg %) and 486 cases belonged to group 3 (TSB > 25mg %). It was found 137 (11.3%) cases positive for G6PD-deficinecy from 1214 children of group 1, 51(5.7%) cases from 900 children of group 2 and 112 (23%) cases from 486 children of group 3 had G6PD-deficinecy. There was statistically significant difference of G6PD-deficinecy between group 2 and 3 (p ≤ 0.001), but between group 1 vs 2 and 1 vs 3 no statistically significant difference was found. The present study indicates, G6PD-deficinecy as a major cause of hyperbilirubinemia and decrease the hemoglobin level less than 14mgdl. Key words: G6PD-deficinecy, Hyperbilirubinemia, Hemoglobin, children.

Statistics Article View: 188 PDF Download: 78