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Effect Of Alcoholic Extract Of Withania Somnifera On Antioxidant Enzymes In Mice With Induced Mammary Carcinoma | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 24, Issue 4, 2013, Pages 37-48 | ||
| Author | ||
| Shalal M.Hussain | ||
| Abstract | ||
| The extract from Withania somnifera roots has been used as medicinal remedy and reported to retain antimicrobial and antimutagenic activities. Random-bred virgin female mice (6-8 wk old) procured from Central Animal House, Iraqi center for cancer and medical genetic research, Almustansyria University. Mice were housed in polypropylene cages. All the mice were allowed to have free access to clean drinking water and standard animal pellet diet formulated on scientific backgrounds throughout the experiment .Sixty female mice were divided into three groups: control, mice transplanted tumor with out alcoholic extract treated and mice with transplanted tumor treated with alcoholic extract. Each group content twenty mice. Mice were intragastrically administered with 20 mg/Kg of Withania somnifera Dun extract by using feeding syringes. Animals treated with extract received a single dose of 20 mg/Kg of Withania somnifera Dun intra gastrically daily for a period of 45 days. After the experimental period of 45 days, the total superoxide dismutase (SOD) and Catalase (CAT) enzymes for both control and experimental groups was investigated. Results: measurement of antioxidant enzymes (SOD, CAT) shows significant differences between mice treated and non treated to alcoholic extract of Withania somnifera roots when compared to negative control (P ≤0.05, 0.01) respectively. The mean of (SOD) level in treated mice is (4.16 U/ml) while the mean of untreated mice is (2.56 U/ml). The mean of SOD in normal mice is (4.86 U/ml) .On the other hand, the mean of (CAT) level in treated mice is (0.062 ± 0.007 U/ml) and in untreated mice is (0.048±0.006 U/ml).while the mean in normal mice (0.078± 0.022 U/ml).Conclusion: the result show a significant elevation in antioxidant enzymes, and these result represented an indicator, for useful extract as treatment of cancer. | ||
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