Factors Affecting Rh Isoimmunization and Suggested Protective Measures

Abdulzahra Shrba, Shamil; Hadi Saheb, Basim

	Factors Affecting Rh Isoimmunization and Suggested Protective Measures
Medical Journal of Babylon
Article 1, Volume 10, Issue 4, 2013, Pages 904-915
Authors
Shamil Abdulzahra Shrba; Basim Hadi Saheb
Abstract
Background: Hemolytic disease of newborn due Rh incompatibility is an important cause of hemolytic anemia and jaundice in newborn. Objectives: To study the prevalence of Rh isoimmunization in our society and to define its risk factors and efficacy of protective measures. Patients and methods: A prospective study was conducted on 120 Rh positive neonates whom their mothers are Rh negative delivered in AL-Zahra teaching Hospital in An Najaf city during the period from the first of May; 2010 till 31st of July; 2010. A full history was taken from their close family members. Thorough clinical examination and investigations were done . Results: Seventy six of study group were males (63.3%) and 44 were females (36.7%),with male to female ratio 1.7:1 and full term were 109(90.8%) and preterm were 11(9.2%). Development of jaundice due to Rh isoimmunization has significant association with the absence of maternal knowledge of her blood group and Rh and her husband blood group and Rh , increase maternal parity, and Siblings history of previous hospital admission due to neonatal indirect hyperbilirubinemia while previous blood transfusion to the mother didn’t have that association. Regular human anti-D immune globulin administration after each delivery of Rh positive neonate and abortion and ABO incompatibility associated with decreased risk of development of jaundice due to Rh isoimmunization. Conclusion: Poor antenatal care regarding Rh negative pregnant women is still a major problem in our society and it’s a significant risk factor for Rh isoimmunization , regular administration of human anti-D globulin is a protective measure.

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