The Relationship between Tumour Necrosis Factor -alpha, IgE Levels and Oxidative Stress In Iraqi Patients with Allergic Rhinitis

H. Abed Tawfik Al-Khyat, Tarek; Hussain Alturaihy, Safaa; Abbass Ali, Zinah

	The Relationship between Tumour Necrosis Factor -alpha, IgE Levels and Oxidative Stress In Iraqi Patients with Allergic Rhinitis
Medical Journal of Babylon
Article 1, Volume 10, Issue 4, 2013, Pages 969-975
Authors
Tarek H. Abed Tawfik Al-Khyat; Safaa Hussain Alturaihy; Zinah Abbass Ali
Abstract
Aim of the study To find out the relation between tumour necrosis factor alpha (TNF-α), immunoglobulin-E and antioxidant levels in the patients with mild or moderate/severe cases. Ninety subject (male , female) were enrolled in this study .Fifty patients with AR were subdivided into two groups i.e. mild (comprising 20 patients) with allergic rhinitis, moderate/ severe (comprising 30 patients) with allergic rhinitis. Forty subjects who are apparently healthy were taken as a control group. Serum TNF-α and IgE were determind by using enzyme- linked immunosorbent assay (ELISA). Malondialdehyde (MDA)levels and catalase activity were determined by using colorimetric method. Serum levels of TNF-α was significantly higher in mild and moderate/severe groups compared with control group (p<0.01). IgE and MDA were significantly higher in mild group ( p< 0.05) and in moderate/severe group(p< 0.01). Catalase was significantly decreased in mild and moderate/severe groups compared with control group (p<0.05) (p<0.01) respectively .A significant positive correlation between TNF-α , IgE and MDA in AR patients in mild and moderate/severe cases. A significant negative correlation between TNF-α ,IgE and catalase in AR patients in mild and moderate/severe cases. Oxidative stress stimulate the production of TNF-α and IgE in patients of AR.

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