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Some hematological and biochemical changes on patients with chronic liver diseases and cirrhosis among random samples of Iraqi people | ||
| Al-Ma'mon College Journal | ||
| Article 1, Volume 0, Issue 22, 2018, Pages 244-253 | ||
| Author | ||
| Amany M. Jasim | ||
| Abstract | ||
| Chronic liver diseases tend to be progressively destroyed in liver tissue. Infections are symptomatic or have only mild nonspecific symptoms as long as cirrhosis is not present. The most frequent complaint of those patients are fatigue, less common manifestations are nausea, weakness, myalgia, arthralgia and weight loss. Materials and Methods :This study included ninety one individuals, their ages ranged from 12 to 73 years (45 male and 46 female) attending the Gastroenterology and Hepatology Center and Baghdad Teaching Hospital during a period starting 2010 to April 2011 to investigate the presence of HBV, HCV and cirrhosis antibodies in serum samples included in this study. Biochemical analyses also were carried out which included estimation of level of total serum bilirubin,aspartateaminotransferaseAST(GPT) and alanine amino transferase ALT( GOT).Hematological tests were also carried out which included prothrombin time ( PT) and Partial thrombin (PTT). Specimens of liver biopsy were taken from patients with cirrhosis of the liver who have been subjected to surgery collected from patients with liver cirrhosis for pathological studies. Results :The results suggest that infection with chronic liver diseases and cirrhosis increased with age .The infection was also more frequent among female than male compared with healthy individuals. Elevation in values of GPT, G0T, total serum bilirubin, PT and PTT were observed among the infected individuals The main pathological changes in liver fibrosis biopsy was regenerated nodules and presence of inflammatory cells, bile ducts, vessels within the fibrous septa and dense inflammatory cells infiltrate in fibrotic bands of infected liver. | ||
| Keywords | ||
| cirrhosis; prothrombin; Bilirubin; fibrosis; septa | ||
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