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Sulfonation and Substitution of Poly Vinyl Alcohol with Amino Antibiotics | ||
| Journal of University of Babylon | ||
| Article 1, Volume 22, Issue 1, 2014, Pages 401-407 | ||
| Authors | ||
| Firyal M.A; Abeer A.M; Shurooq S. K; Wessal M. Kh; Nedhal M. Kh | ||
| Abstract | ||
| Colon specific drugs release were synthesized from modification of PVA by sulfonation of hydroxyl groups were carried out by usingchlorosulfonic acid at 0ºC.The substitution of sulfonyl group with amino antibiotics such as amoxilline and cephalexinewere occurred ,with high conversion percentage,the novel prepared drug polymers were characterized by H.NMR, FT.IR and UV. Spectroscopies. Physical properties were studied and controlled drug release behaviors were studied in different pH values at 37ºC. The swelling % were calculated in acidic medium at 37ºC to protected the prodrug polymer from hydrolysis in acidic stomach environment , and let it to hydrolyzed in basic medium of intestinal, as specific site. It was found that the rate of release showed dependence on the pH of the medium within the colon pH. | ||
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