Study of Activin A and Inhibin A Hormones levels in Polycystic Ovarian Syndrome and their Correlation with Other Biochemical Parameters

Kadhem Al-Hakeim, Hussein; Abdul Saheb Ridha, Maha

	Study of Activin A and Inhibin A Hormones levels in Polycystic Ovarian Syndrome and their Correlation with Other Biochemical Parameters
Magazine of Al-Kufa University for Biology
Article 1, Volume 5, Issue 2, 2013, Pages 86-93
Authors
Hussein Kadhem Al-Hakeim; Maha Abdul Saheb Ridha
Abstract
Polycystic ovary syndrome (PCOS) is very common endocrinological disorder in premenapusal women. Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activin enhances FSH biosynthesis and secretion, and participates in the regulation of the menstrual cycle. Many other functions have been found to be exerted by activin, including roles in cell proliferation, differentiation, apoptosis (8)metabolism, homeostasis, immune response, wound repair and endocrinefunction. Activin and Inhibin are produced in the gonads, pituitary gland, placenta, and other organs. The results of the present study showed that serum Inhibin A level is low in PCOS, while no difference in the level of serum Activin A in PCOS patients in comparing with control group. The results of the present study showed that serum Inhibin A was negatively correlated with age,and Directly correlated with serum Testosterone and E2. Activin A level in PCOS women showed a significant Positive correlation with LH and LH/FSH ratio
Keywords
Polycystic ovary syndrome; protein complexes; FSH biosynthesis; gonads; Pituitary gland; Placenta; PCOS; FSH

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