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Urokinase – type Plasminogen Activator System in Human Breast Cancer | ||
| Iraqi Journal of Science | ||
| Article 1, Volume 54, Issue 5, 2013, Pages 1050-1056 | ||
| Authors | ||
| Reyadh Salim Al-Jubouri; Faeza Aftan Al-Rawi; Ali Hussien Al-Khafaji | ||
| Abstract | ||
| Urokinase plasminogen activator (uPA), urokinase plasminogen activator receptor (uPAR) and plasminogen activator inhibitor-1(PAI-1) are essential for metastasis, and overexpression of these molecules is strongly correlated with poor prognosis in a variety of malignant tumors. This study revealed direct correlation between immunohistochemical expression of uPA with pathological stage. No significant association of immunohistochemical expressions of uPA, uPAR and PAI-1 with immunohistochemical expressions for estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor -2 (HER-2/neu), and direct association between immunohistochemical expressions of (uPA and uPAR) as well as between immunohistochemical expressions of (uPA and PAI-1). | ||
| Keywords | ||
| Breast cancer; uPA; uPAR; PAI; Tissue microarray | ||
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