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Synthesis of some New 1,2,4-Triazole derivatives | ||
| Journal of University of Anbar for Pure Science | ||
| Article 21, Volume 7, Issue 1, 2013, Pages 81-90 PDF (789.91 K) | ||
| Document Type: Research Paper | ||
| DOI: 10.37652/juaps.2013.83187 | ||
| Author | ||
| Ibtehal Kahtan Abdullah* | ||
| University Of Tikrit – College Of Science. | ||
| Abstract | ||
| In the present work, compound 3-arylidene amino-5-methyl-1,2,4-triazole (IIIa-c), required as starting material obtained in one-pot reaction by condensing 5-methyl-3-amino-1,2,4-triazole with different aromatic aldehydes. The required 5-methyl-3-amino-1,2,4-triazole was prepared from treatment of acetyl urea (I) with hydrazine hydrate, the compounds (IIIa-c) were converted to the corresponding [3-[5-methyl-1,2,4-triazol-2-yl]-2-arylthiazolidine-4-one (Va1-a3) and imidazoleine-4-one (Vb1-b3) by reacted it with thioglycolic acid and Glycine in absolute ethanol. The compounds (IIa-c) were converted also to 2-methyl-5-arylamino-5,6,-dihydroimidozo[2,1-b]-1,2,4-triazole (VIIIa-VIIIc) reacted with TCA then with aniline derivatives. The linear pathway strategy of all these synthesized compounds can be summarized in scheme (1). | ||
| Keywords | ||
| synthesis; Triazole derivatives | ||
| References | ||
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