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Synthesis of Some Mannich and 2,5-Disubstituted4-Thiazolidinone Compounds Derived from 4-amino Sulphamethaoxazole | ||
| Kirkuk Journal of Science | ||
| Article 1, Volume 8, Issue 3, 2013, Pages 65-74 PDF (0 K) | ||
| DOI: 10.32894/kujss.2013.83421 | ||
| Authors | ||
| Khalid A. Al-Badrany; Ayad S. Hamad; Ihmood K. Al-Juboori | ||
| Abstract | ||
| 4-Chloro acetyl amino sulphamethaoxazole (A1) was synthesized by the reaction of amino sulphamethaoxazole with chloro acetyl chloride, Then refluxed with ammonium thiocyanate to obtain thiazoldine-4-one (A 2) . (A2) was stirred with formaldehyde and various secondary amines to gain 5 novel compounds Mannich bases(A 3-7 ).and 2,5-Disubstituted thiazolidine-4-one (A 8-11) were synthesized by the reaction of substituted benzyldehyd with Compound (A2) . The structure of the synthesized compounds are confirmed by I.R, 1 H-NMR & 13 C-NMR spectra and Some chemical physical data | ||
| Keywords | ||
| synthesis Mannich bases; Disubstituted; thiazolidinones | ||
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