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Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients | ||
| Journal of the Faculty of Medicine | ||
| Article 1, Volume 51, Issue 1, 2009, Pages 43-47 | ||
| Authors | ||
| Raghad J H AL-Akayshi; Khalida M. Mousawy; Eman Sh. AL-Obeidy | ||
| Abstract | ||
| Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis.Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor.Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out.Key words: AIH, HLA antigen, PCR-SSP. | ||
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